Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway:a key target against neurodegenerative diseases?
Mirjana Antonijevic
Patrick Dallemagne
Christophe Rochais
Normandie University,UNICAEN,CERMN,Caen,France
摘要：Brain-derived neurotrophic factor(BDNF)is one of the neurotrophins,a specific polypeptide growth factor,which plays a crucial role in the proliferation,differentiation,survival,and death of neurons and non-neuronal cells.It is not only essential to maintain the balance between death on one side and survival of neurons on the other,but also it mediates additional higher-order activities such as learning,memory,and behavior.It is initially synthesized as a precursor protein,proBDNF,that can be secreted as it is or it can be cleaved intracellularly by furin and proconvertases,or extracellularly by extracellular proteases such as matrix metalloprotease-9 and matrix metalloprotease-2,or plasmin to give mature BDNF.
机标关键词：regenerationpathwayneurodbdnftargettrkbagainstdegenerative
论文发表日期：2024-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 495-496 )