Detection and clearance in Alzheimer's disease:leading with illusive chemical,structural and morphological features of the targets
Luís Gales
i3S-Instituto de Investigação e Inovação em Saúde,Rua Alfredo Allen,Porto,Portugal;IBMC-Instituto de Biologia Molecular e Celular,Universidade do Porto,Rua Alfredo Allen,Porto,Portugal;ICBAS-Instituto de Ciências Biomédicas Abel Salazar,Rua de Jorge Viterbo Ferreira,Porto,Portugal
摘要：Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex organisms.The same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance purposes.Unfortunately,interference in biological systems is not that simple.For a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a"soup"of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer's disease is given.
机标关键词：morphologicalalzheimerchemicaldetectionwithclearancediseasefeatures
论文发表日期：2024-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 497-498 )