On-chip physiological mimicry of neurovascular unit:challenges and perspectives
Song Ih Ahn1
YongTae Kim2
1.School of Mechanical Engineering,Pusan National University,Busan,South Korea2.George W.Woodruff School of Mechanical Engineering,Georgia Institute of Technology,Atlanta,GA,USA;Parker H.Petit Institute for Bioengineering and Bioscience,Georgia Institute of Technology,Atlanta,GA,USA;Wallace H.Coulter Department of Biomedical Engineering,Georgia Institute of Technology,Atlanta,GA,USA;Institute for Electronics and Nanotechnology,Georgia Institute of Technology,Atlanta,GA,USA
摘要：Neurological disorders including neurodegenerative diseases,brain tumors,and stroke are the second leading cause of death and the greatest cause of disability worldwide.However,it remains challenging to achieve effective drug delivery to the central nervous system for treatments of neurological diseases due to the blood-brain barrier(BBB).The function of the BBB is regulated by the physiological interactions between various types of cells in the neurovascular unit(NVU).In the NVU,the brain vasculature of the BBB is surrounded by brain pericytes,brain astrocytes,neurons,and microglia(Figure 1).Moreover,the NVU at the levels of arteries and veins includes contractile smooth muscle cells(Schaeffer and ladecola,2021).
机标关键词：challengesmimicryneurovascularon-chipperspectivesphysiologicalunit
论文发表日期：2024-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 499-500 )