Astrocytes dynamically regulate the blood-brain barrier in the healthy brain
Agné Pociūté1
Augustas Pivoriūnas1
Alexei Verkhratsky2
1.Department of Stem Cell Biology,State Research Institute Centre for Innovative Medicine,Vilnius,Lithuania2.Department of Stem Cell Biology,State Research Institute Centre for Innovative Medicine,Vilnius,Lithuania;Faculty of Biology,Medicine and Health,The University of Manchester,Manchester,UK;Achucarro Centre for Neuroscience,IKERBASQUE,Basque Foundation for Science,Bilbao,Spain;Department of Forensic Analytical Toxicology,School of Forensic Medicine,China Medical University,Shenyang,Liaoning Province,China
摘要：The blood-brain barrier(BBB)(discovered and defined by Max Lewandowsky and Lina Stern,and not,as it is universally,and yet erroneously believed,by Paul Ehrlich(Verkhratsky and Pivoriunas,2023))that separates the nervous system from the circulation is evolutionarily conserved from arthropods to man.The primeval BBB of the invertebrates and some early vertebrates was made solely by glial cells and secured(in invertebrates)by septate junctions;in most vertebrates,including mammals,the barrier is associated with endothelial cells and secured with tight junctions.
机标关键词：barrierastrocytesblood-braindynamicallyhealthyregulate
论文发表日期：2024-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 709-710 )