Latest assessment methods for mitochondrial homeostasis in cognitive diseases
Wei You1
Yue Li2
Kaixi Liu2
Xinning Mi2
Yitong Li2
Xiangyang Guo3
Zhengqian Li3
1.Department of Anesthesiology,Peking University Third Hospital,Beijing,China;Peking University Third Clinical Medical College,Beijing,China2.Department of Anesthesiology,Peking University Third Hospital,Beijing,China3.Department of Anesthesiology,Peking University Third Hospital,Beijing,China;Beijing Center of Quality Control and Improvement on Clinical Anesthesia,Beijing,China;Anesthesia and Perioperative Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care(CPAM),Beijing,China
摘要：Mitochondria play an essential role in neural function, such as supporting normal energy metabolism,regulating reactive oxygen species, buffering physiological calcium loads, and maintaining the balance of morphology, subcellular distribution, and overall health through mitochondrial dynamics. Given the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, mild cognitive impairment, and postoperative cognitive dysfunction. This review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences, from the perspectives of energy metabolism, oxidative stress, calcium homeostasis, and mitochondrial dynamics (including fission-fusion, transport, and mitophagy).
机标关键词：cognitiveassessmentdiseaseshomeostasislatestmethodsmitochondrial
论文发表日期：2024-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 754-768 )
英文信息