Does astrocytic L-lactate enhance cognition through myelination?
Mastura Akter1
Ying Li2
1.Department of Neuroscience,City University of Hong Kong,Hong Kong Special Administrative Region,China;Department of Biomedical Sciences,City University of Hong Kong,Hong Kong Special Administrative Region,China2.Department of Neuroscience,City University of Hong Kong,Hong Kong Special Administrative Region,China;Department of Biomedical Sciences,City University of Hong Kong,Hong Kong Special Administrative Region,China;Centre for Regenerative Medicine and Health,Hong Kong Institute of Science & Innovation,Chinese Academy of Sciences,Hong Kong Special Administrative Region,China;Centre for Biosystems,Neuroscience,and Nanotechnology,City University of Hong Kong,Hong Kong Special Administrative Region,China
摘要：Introduction:Astrocytes,the predominant glial cell in the brain,play a vital role in a plethora of central nervous system functions.They are the major storage site of glycogen in the central nervous system.They produce L-lactate by glycogenolysis and glycolysis which is then transported to neurons(Magistretti and Allaman,2018).Multiple evidence using diverse behavioral paradigms,such as fear conditioning,conditioned place avoidance,rat gambling task(RGT),and flavor-place paired associate(PA)learning suggest that L-lactate has a beneficial effect on various aspects of cognition(Wang et al.,2017;Akter et al.,2023b).
机标关键词：l-lactatethroughastrocyticcognitiondoesenhancemyelination
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1167-1168 )