CRABP1-mediated non-canonical retinoic acid signaling in motor neurons and neural stem cells
Li-Na Wei
Department of Pharmacology,University of Minnesota Medical School,Minneapolis,MN,USA
摘要：Retinoic acid(RA),the active metabolite of vitamin A(the retinoids),elicits a wide spectrum of biological activities critical to the development and health of most of the organ systems including the nervous systems(Corcoran et al.,2002).The effects of RA are mediated by two very distinct pathways;the first is manifested in the nucleus by binding to a large family of nuclear RA receptors(RARs)to regulate proper expression of RA-targeted genes,and the second occurs in the cytoplasm by binding to a specific cytoplasmic protein named cellular RA binding protein 1(CRABP1)to modulate specific cytosolic signaling(Nhieu et al.,2022).
机标关键词：stemcellsmotoracidcrabp1-mediatedneuralneuronsnon-canonical
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1169-1170 )