Building the toolbox for in vivo glia-to-neuron reprogramming
Ye Xie
Bo Chen
Departments of Ophthalmology and Neuroscience,Icahn School of Medicine at Mount Sinai,New York,NY,USA
摘要：Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously,the central nervous system in adult mammals lacks the ability to compensate for the neuronal loss caused by neurodegenerative diseases or traumatic injuries resulting in permanent loss of functionality.Inspired by earlier discoveries that radial glia or astrocytes isolated from the postnatal cortex can generate neurons,and fully differentiated somatic cells can be"reprogrammed"back to a pluripotent state driven by defined transcription factors,regenerative strategies to reprogram resident glial cells,such as astrocytes,Müller glia(MG),NG2-glia,and microglia,into neurons in vivo has emerged during the past decade.Theoretically,terminally differentiated cells could be converted from one fate to another using this strategy,especially when cells are lineage-related or originated from a common ancestor.
机标关键词：toolboxbuildingvivoglia-to-neuronreprogramming
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1171-1172 )