Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease
Vinata Vedam-Mai1
Jacob M.Samuel2
Boone M.Prentice2
1.Department of Neurology,University of Florida,Gainesville,FL,USA2.Department of Chemistry,University of Florida,Gainesville,FL,USA
摘要：Parkinson's disease-A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched in α-synuclein(α-syn),known as Lewy bodies,which are not only composed of proteins,but also a core of lipid species.PD has been thus far principally thought of as a"proteinopathy"caused by the misfolding of α-syn.However,there is a major role for certain lipids in modulating α-syn physiology in the brain and both decreased and increased membrane interactions and interactions with specific fatty acids are potential triggers for α-syn oligomerization and fibril formation.
机标关键词：parkinsonmolecularimagingrolemassdiseaselipidsmicroscope
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1179-1180 )