Influence of aging,mitochondrial dysfunction,and inflammation on Parkinson's disease
Davide Cossu1
Nobutaka Hattori2
1.Department of Neurology,Juntendo University,Tokyo,Japan;Department of Biomedical Sciences,Sassari University,Sassari,Italy2.Department of Neurology,Juntendo University,Tokyo,Japan
摘要：Aging is associated with chronic form of inflammation called inflammaging,which results from immune system changes.Inflammaging plays a crucial role in the pathogenesis of various neurodegenerative diseases(Dabravolski et al.,2022).Moreover,aging-related inflammation can be triggered by disrupted mitophagy,where the accumulation of molecular patterns associated with mitochondrial damage in the cytosol leads to the production of inflammatory cytokines and activation of the immune response.In our recent research,we investigated the impact of aging and mitochondrial dysfunction on neuroinflammation using a model of central nervous system(CNS)neuroinflammation in mice that lack genes associated with familial Parkinson's disease(PD;Figure 1).
机标关键词：parkinsonagingdiseasedysfunctioninflammationinfluencemitochondrial
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1197-1198 )