Investigating epithelial-neuronal signaling contribution in visceral pain through colon organoid-dorsal root ganglion neuron co-cultures
Francesco Margiotta1
Lorenzo Di Cesare Mannelli1
Antonino Morabito2
Carla Ghelardini1
Elena Lucarini1
1.Department of Neuroscience,Psychology,Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section,University of Florence,Florence,Italy2.Department of Neuroscience,Psychology,Drug Research and Child Health-NEUROFARBA,University of Florence,Florence,Italy;Meyer Children's Hospital IRCCS,Florence,Italy
摘要：Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs),affecting about 20％of the global population(Grundy et al.,2019).Current pain therapies are poorly effective on visceral pain of intestinal origin and present several side effects,hence the need to identify novel molecular and cellular targets for drug development.
机标关键词：throughrootco-culturescoloncontributionepithelialganglioninvestigating
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1199-1200 )