K+channel-mediated retarded maturation of interneurons and its role in neurodevelopmental disorders
Kaizhen Li1
Daria Savitska2
Olga Garaschuk2
1.Laboratory of Systems Neuroscience,Department of Physiology,University of Bern,Bern,Switzerland2.Institute of Physiology,Department of Neurophysiology,Eberhard Karls University of Tübingen,Tübingen,Germany
摘要：De novo mutations in genes encoding K+channels are implicated in many severe neurodevelopmental disorders.Specifically,mutations in KCNA2,encoding the Shaker-type voltage-gated K+channel Kv1.2,and KCNJ2,encoding the inwardly rectifying K+channel Kir2.1,associate with focal and generalized epilepsies,brain atrophy,autism,ataxia and hereditary spastic paraplegia(Syrbe et al.,2015;Masnada et al.,2017;Cheng et al.,2021).
机标关键词：channelneurodroledevelopmentaldisordersinterneuronsmaturationmediated
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1403-1404 )