Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis
Naomi Hartopp1
Andrea Markovinovic2
Christopher CJ Miller2
Patricia Gomez-Suaga3
1.Sheffield Institute for Translational Neuroscience,University of Sheffield,Sheffield,UK2.Department of Basic and Clinical Neuroscience,Institute of Psychiatry,Psychology and Neuroscience,London,UK3.Universidad de Extremadura.Departamento de Bioquímica y Biología Molecular y Genética,Facultad de Enfermería y Terapia Ocupacional,Cáceres,Spain;Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos Ⅲ(CIBER-CIBERNED-ISCⅢ),Madrid,Spain;Instituto Universitario de Investigacion Biósanitaria de Extremadura(INUBE),Cáceres,Spain
摘要：Amyotrophic lateral sclerosis(ALS)is a fast-progressing fatal neurodegenerative disease and the most common form of motor neuron disease.There is currently no cure and approximately 90％of cases are sporadic.ALS shares genetic causes,clinical and neuropathological features with frontotemporal dementia,the second most common form of presenile dementia.ALS and frontotemporal dementia are therefore considered a disease spectrum(Abramzon et al.,2020).Various cellular disruptions contribute to disease pathogenesis making effective treatment via a single target challenging.Therapeutic interventions that modulate multiple cellular mechanisms may therefore be most effective in treating such complex diseases.
机标关键词：insighthumanamyotrophiccontactsendoplasmicintolateralmitochondria
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1407-1408 )