Medin synergized with vascular amyloid-beta deposits accelerates cognitive decline in Alzheimer's disease:a potential biomarker
Xiao Ge1
Li Li2
Chunming Xie3
1.Department of Neurology,Affiliated Zhongda Hospital,School of Medicine,Southeast University,Nanjing,Jiangsu Province,China2.Center of Health Management,Affiliated Zhongda Hospital,School of Medicine,Southeast University,Nanjing,Jiangsu Province,China3.Department of Neurology,Affiliated Zhongda Hospital,School of Medicine,Southeast University,Nanjing,Jiangsu Province,China;Institute of Neuropsychiatry,Affiliated Zhongda Hospital,Southeast University,Nanjing,Jiangsu Province,China;The Key Laboratory of Developmental Genes and Human Disease,Southeast University,Nanjing,Jiangsu Province,China
摘要：Brain vascular dysfunction in Alzheimer's disease(AD)pathogenesis has become increasingly clear.Accumulating evidence shows that damaged vascular,including large or small vessels and even neurovascular unit,may accelerate the neuropathological process of AD via disrupting brain hypoperfusion,aberrant angiogenesis,and neuroinflammatory response,etc.Thus,vascular dysfunction makes a substantially contribution to the cognitive decline of AD patients.However,how these blood vessels and pathological markers of AD link or interact to influence cognitive function remains unclear.
机标关键词：alzheimercognitivewithacceleratesamyloid-betabiomarkerdeclinedeposits
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：1( 1414 )