Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation
Chin-Tong Ong1
Zhen-Kai Ngian2
1.Temasek Life Sciences Laboratory and Department of Biological Sciences,National University of Singapore,Singapore,Singapore2.Department of Genetics,Harvard Medical School,Boston,MA,USA;Institute of Molecular and Cell Biology,Agency for Science,Technology and Research,Singapore,Singapore
摘要：Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing organismal vulnerability to age-onset diseases and morbidity.Studies in different animal models have led to the identification of twelve aging hallmarks that shared several features:its age-associated manifestation,how experimental manipulation of individual hallmark may alter the trajectory of aging,as well as their interdependence during the process of aging.These hallmarks include genomic instability,telomere attrition,loss of proteostasis,disabled macro-autophagy,deregulated nutrient-sensing,mitochondrial dysfunction,cellular senescence,stem cell exhaustion,chronic inflammation,dysbiosis,altered intercellular communication and epigenetic alterations(Lopez-Otin et al.,2023).
机标关键词：polymeraseagingelongationnelf-aregulation
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1415-1416 )