Aberrant adult neurogenesis in intractable epilepsy:can GABAergic progenitor transplantation normalize this process?
Muhammad N.Arshad1
Janice R.Naegele2
1.Department of Biology,Wesleyan University,Middletown,CT,USA;Department of Neuroscience,Tufts University School of Medicine,Boston,MA,USA2.Department of Biology,Wesleyan University,Middletown,CT,USA
摘要：Temporal lobe epilepsy(TLE)is a common type of focal epilepsy characterized by seizure foci within the temporal lobes.While surgical resection of the foci is an established and effective approach for controlling seizures,both temporal lobes cannot be removed,due to their prominent roles in learning and memory.Additionally,seizures induce changes to the temporal lobes that contribute to hyperexcitability,including mossy fiber sprouting,astrogliosis,granule cell(GC)dispersion,and loss of amma-aminobutyric acid(GABA)ergic interneurons(Swartz et al.,2006;Ammothumkandy et al.,2022).
机标关键词：processadultthisaberrantepilepsygabaergicintractableneurogenesis
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1419-1420 )