A dysregulated calcium homeostasis as the earliest pathological sign in stem cell-derived Parkinson's disease neurons?
Nilima Prakash
Working Group Human Stem Cell Research,Department Hamm 2,Hamm-Lippstadt University of Applied Sciences,Hamm,Germany
摘要：Parkinson's disease(PD)is characterized by the slow and progressive demise of dopamine(DA)-synthesizing neurons in the substantia nigra pars com pacta(SNc),a nucleus located in the human ventral midbrain.Neuron death also affects other regions in the brain at later stages of PD.The concomitant lack of DA in the human forebrain(striatum)leads to the typical motor symptoms of this still uncurable neurodegenerative disorder.
机标关键词：parkinsonstemsigncalciumcell-deriveddiseasedysregulatedearliest
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1421-1422 )