Working toward an integrated plasticity/network framework for repetitive transcranial magnetic stimulation to inform tailored treatments
Jessica Moretti
Jennifer Rodger
Experimental and Regenerative Neurosciences,School of Biological Sciences,University of Western Australia,Crawley,WA,Australia;Brain Plasticity Lab,Perron Institute for Neurological and Translational Science,Nedlands,WA,Australia
摘要：Non-invasive brain stimulation techniques(NIBS),including repetitive transcranial magnetic stimulation(rTMS)and transcranial electric stimulation(tES),are increasingly being adopted clinically for treatment of neuropsychiatric and neurological disorders,albeit with varying success.The rationale behind the use of NIBS has historically been that stimulation techniques modulate neuronal activity in the targeted region and consequently induce plasticity which can lead to therapeutic outcomes.However,over the past decade,there has been a marked increase in our understanding of the neurobiological mechanisms of NIBS,in particular for rTMS.The increasing breadth of research in humans and animal models has resulted in a more nuanced understanding of how NIBS affects the brain with the hope for improved therapeutic applications.In this perspective we summarize some of the newly identified mechanisms contributing to NIBS effects,focusing on rTMS,and propose how emerging experimental techniques could be leveraged to further understand and optimize non-invasive brain stimulation.
机标关键词：frameworkintegratedworkinginformnetworkmagneticplasticityrepetitive
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1423-1424 )