NLRP3 inflammasome plays a vital role in the pathogenesis of age-related diseases in the eye and brain
Jack Jonathan Maran
Odunayo Omolola Mugisho
Buchanan Ocular Therapeutics Unit,Department of Ophthalmology,New Zealand National Eye Centre,University of Auckland,Auckland,New Zealand
摘要：Key points:With aging,there is increased nucleotide-binding oligomerization domain-(NOD-)like receptor(NLR)protein-3(NLRP3)activation in neural and ocular tissues.Activation of the NLRP3 inflammasome appears to be a common denominator in the pathogenesis of age-related diseases of the eye and brain.Pharmacological inhibition of the NLRP3 inflammasome may be a potent therapy for preventing the development and progression of age-related eye and brain diseases.
机标关键词：nlrp3vitalbrainroleage-relateddiseasesinflammasomepathogenesis
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1425-1426 )