Using microglia-derived extracellular vesicles to capture diversity of microglial activation phenotypes following neurological injury
Austyn D.Roseborough
Nikita Ollen-Bittle
Shawn N.Whitehead
Vulnerable Brain Laboratory,Department of Anatomy & Cell Biology,Schulich School of Medicine & Dentistry,London,OH,Canada
摘要：Microglia are one of the three glial cell populations in the central nervous system(CNS),along with astrocytes and oligodendrocytes.While microglia are unique among brain cells due to their hematologic origin and perform immune functions similar to peripheral macrophages,they are not simply macrophages of the CNS.Microglia are crucial for many brain-specific functions such as synaptic pruning,facilitation of myelin turnover and communication with both neurons and astrocytes(Saijo and Glass,2011).They are a highly active cell type,constantly surveying their environment and responding to both exogenous and endogenous danger signals which can include reactive oxygen species,cytosolic DNA,heat shock proteins,plasma proteins and microbial components.
机标关键词：diversityactivationcapturederivedextracellularfollowinginjurymicroglial
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1633-1634 )