Sexual dimorphism of G protein-coupled receptor signaling in the brain
Sara Aljoudi1
Hamdan Hamdan2
Khaled S.Abd-Elrahman3
1.Department of Physiology and Immunology,College of Medicine and Health Sciences,Khalifa University,Abu Dhabi,United Arab Emirates2.Department of Physiology and Immunology,College of Medicine and Health Sciences,Khalifa University,Abu Dhabi,United Arab Emirates;Healthcare Engineering Innovation Center(HEIC),Khalifa University,Abu Dhabi,United Arab Emirates3.Department of Anesthesiology,Pharmacology and Therapeutics,and Djavad Mowafaghian Center for Brain Health,University of British Columbia,Vancouver,BC,Canada;Department of Pharmacology and Therapeutics,College of Medicine and Health Science,Khalifa University,Abu Dhabi,United Arab Emirates;Department of Pharmacology and Toxicology,Faculty of Pharmacy,Alexandria University,Alexandria,Egypt
摘要：G protein-coupled receptors(GPCRs)represent the most substantial family of membrane receptors that are targeted by U.S.Food and Drug Administration-approved drugs.Much of the preclinical research to understand the pharmacology of many membrane receptors including GPCRs is derived from studies in male animal models(Karp and Reavey,2019).This can be of concern as emerging evidence reveals unexpected sex-dependent differences in GPCR pharmacodynamics.Thus,understanding the sex-specific disparities in GPCR pharmacological fingerprints can aid in developing targeted ligands that precisely correct GPCR signaling modalities in men and women and ultimately,enhance their effectiveness for certain pathophysiological conditions.We will attempt to summarize the current evidence supporting the sex-biased signaling of GPCRs implicated in several brain disorders.
机标关键词：receptorsexualbraindimorphismprotein-coupledsignaling
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1635-1636 )