Monomeric C-reactive protein:a link between chronic inflammation and neurodegeneration?
Nicoleta Arnaut1
Ylenia Pastorello2
Mark Slevin3
1.George Emil Palade University of Medicine,Pharmacy,Science and Technology,Targu Mures,Romania2.Department of Anatomy and Embryology,George Emil Palade University of Medicine,Pharmacy,Science and Technology,Târgu Mures,Romania3.Center for Advanced Medical and Pharmaceutical Research(CCAMF),George Emil Palade University of Medicine,Pharmacy,Science and Technology,Târgu Mures,Romania
摘要：Pre-diabetic insulin resistance is associated with sub-clinical inflammation and concomitant increase in systemic C-reactive protein(CRP)levels.Type 2 diabetes mellitus(T2DM)patients register even higher chronic levels of inflammation,with excess circulating CRP originating from both typical hepatic synthesis,and also visceral white adipose tissue.In addition,infiltration of pro-inflammatory macrophages into the expanding fat,as obesity becomes morbid,contributes further to dysregulation and symptomatic disease(Stanimirovic et al.,2022).Most importantly,in diabetic individuals,a sustained and chronic inflammation is perpetuated in the presence of non-healing wounds and ulcers,with associated further increase in CRP(Dangwal et al.,2015).
机标关键词：proteinneurodbetweenlinkc-reactivechronicdegenerationinflammation
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1643-1644 )