Alterations of protein homeostasis in Alzheimer's disease:beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response
Dmitry Lim1
Alexei Verkhratsky2
1.Department of Pharmaceutical Sciences,Università del Piemonte Orientale"Amedeo Avogadro",Novara,Italy2.Faculty of Biology,Medicine and Health,The University of Manchester,Manchester,UK;Achucarro Center for Neuroscience,IKERBASQUE,Basque Foundation for Science,Bilbao,Spain &Department of Neurosciences,University of the Basque Country UPV/EHU and CIBERNED,Leioa,Spain;Department of Stem Cell Biology,State Research Institute Centre for Innovative Medicine,Vilnius,Lithuania;Department of Forensic Analytical Toxicology,School of Forensic Medicine,China Medical University,Shenyang,Liaoning Province,China
摘要：Alzheimer's disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and society.Neuropathological hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.
机标关键词：alzheimerproteinbeyondstressalterationsdiseaseendoplasmichomeostasis
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1645-1646 )