Resident immune responses to spinal cord injury:role of astrocytes and microglia
Sydney Brockie1
Cindy Zhou1
Michael G.Fehlings2
1.Division of Genetics and Development,Krembil Research Institute,University Health Network,Toronto,ON,Canada;Institute of Medical Science,University of Toronto,Toronto,ON,Canada2.Division of Genetics and Development,Krembil Research Institute,University Health Network,Toronto,ON,Canada;Institute of Medical Science,University of Toronto,Toronto,ON,Canada;Division of Neurosurgery and Spine Program,Department of Surgery,University of Toronto,Toronto,ON,Canada
摘要：Spinal cord injury can be traumatic or non-traumatic in origin,with the latter rising in incidence and prevalence with the aging demographics of our society.Moreover,as the global population ages,individuals with co-existent degenerative spinal pathology comprise a growing number of traumatic spinal cord injury cases,especially involving the cervical spinal cord.This makes recovery and treatment approaches particularly challenging as age and comorbidities may limit regenerative capacity.For these reasons,it is critical to better understand the complex milieu of spinal cord injury lesion pathobiology and the ensuing inflammatory response.This review discusses microglia-specific purinergic and cytokine signaling pathways,as well as microglial modulation of synaptic stability and plasticity after injury.Further,we evaluate the role of astrocytes in neurotransmission and calcium signaling,as well as their border-forming response to neural lesions.Both the inflammatory and reparative roles of these cells have eluded our complete understanding and remain key therapeutic targets due to their extensive structural and functional roles in the nervous system.Recent advances have shed light on the roles of glia in neurotransmission and reparative injury responses that will change how interventions are directed.Understanding key processes and existing knowledge gaps will allow future research to effectively target these cells and harness their regenerative potential.
机标关键词：cordroleastrocytesimmuneinjurymicrogliaresidentresponses
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1678-1685 )
英文信息