Breaking the brain barrier:cell competition in neural development and disease
Patrizia Morciano1
Daniela Grifoni2
1.Department of"Life,Health and Environmental Sciences",University of L'Aquila,Italy;"INFN-Laboratori Nazionali del Gran Sasso",Assergi,Italy2.Department of"Life,Health and Environmental Sciences",University of L'Aquila,Italy
摘要：General information on cell competition:Social behaviors are the basis of biological life.Like species and populations,cell communities experience Darwinian ecological interactions,and in case space and nutrient availability are not uniform throughout the tissue,they begin to compete for ground occupancy.In the 1970s,studies carried out by Drosophila geneticists pioneered the concept of cell competition,observing that genetic heterogeneity in a developing tissue led to the elimination of suboptimal cells(called losers)and the concurrent expansion of the fittest(accordingly named winners).This mechanism fits the logic underlying organ development,where tissue heterogeneity due to the intermingling of cells from different compartments may disrupt the entire process.
机标关键词：developmentcompetitionbarrierbraincellbreakingdiseaseneural
论文发表日期：2024-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1863-1864 )