Highly toxic Aβ begets more Aβ
Merc M.Kemeh
Noel D.Lazo
Gustaf H.Carlson School of Chemistry and Biochemistry,Clark University,Worcester,MA,USA
摘要：Alzheimer's disease(AD)is the most common form of dementia-the 7th leading cause of death worldwide.At the tissue level,AD is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-β peptide(Aβ),and by intraneuronal neurofibrillary tangles composed of tau.Molecular genetics of early-onset AD and longitudinal brain-imaging studies of late-onset AD indicate that extracellular Aβ deposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).
机标关键词：morebegetshighlytoxic
论文发表日期：2024-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1871-1872 )