Astrocyte chloride,excitatory-inhibitory balance and epilepsy
Verena Untiet1
Maiken Nedergaard2
Alexei Verkhratsky3
1.Division of Glial Disease and Therapeutics,Center for Translational Neuromedicine,University of Copenhagen,Copenhagen,Denmark2.Division of Glial Disease and Therapeutics,Center for Translational Neuromedicine,University of Copenhagen,Copenhagen,Denmark;Division of Glial Disease and Therapeutics,Center for Translational Neuromedicine,Department of Neurosurgery,University of Rochester Medical Center,Rochester,NY,USA3.Division of Glial Disease and Therapeutics,Center for Translational Neuromedicine,University of Copenhagen,Copenhagen,Denmark;Faculty of Biology,Medicine and Health,The University of Manchester,Manchester,UK;Achucarro Centre for Neuroscience,IKERBASQUE,Basque Foundation for Science,Bilbao,Spain
摘要：Excitation and inhibition are at the core of brain function and malfunction.To sustain the activity of neuronal networks over time and space,glutamatergic excitation is balanced by GABAergic inhibition.The equipoise of excitation and inhibition,known as the excitation/inhibition(E/I)balance,is crucial for proper brain function.The E/I balance is highly dynamic and shifts across different brain states:wakefulness primarily augments excitatory activity,while sleep promotes a decrease in excitation and an increase in inhibition(Bridi et al.,2020).Neuronal activity during various brain states is primarily regulated by neurotransmitters(Schiemann et al.,2015),alongside non-synaptic mechanisms that operate on a slower timescale.The non-synaptic mechanisms are many,with the ionic composition of the extracellular space playing a significant role;altering extracellular ion concentrations affects sleep,arousal,electroencephalogram patterns,and behavioral states(Ding et al.,2016).
机标关键词：balanceastrocytechlorideepilepsyexcitatoryinhibitory
论文发表日期：2024-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：1( 1887 )