Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression
Qiuqin Han1
Wenhui Li1
Peiqing Chen1
Lijuan Wang1
Xiwen Bao1
Renyan Huang2
Guobin Liu2
Xiaorong Chen3
1.Department of Scientific Research,Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital,Shanghai,China2.Department of Traditional Chinese Vascular Surgery,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China3.Department of Physiology,Laboratory of Neurodegenerative Diseases,Changzhi Medical College,Changzhi,Shanxi Province,China
摘要：Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.
机标关键词：depressionstrategiesnlrp3euroinflammasomeinflammationmediatedmicroglial
论文发表日期：2024-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1890-1898 )
英文信息