Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings
Marcello Serra1
Nicola Simola1
Alexia E.Pollack2
Giulia Costa1
1.Department of Biomedical Sciences,Section of Neuroscience,University of Cagliari,Cagliari,Italy2.Department of Biology,University of Massachusetts-Boston,Boston,MA,USA
摘要：Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic effects.Central toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and adults.The present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and nicotine.Detailed elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.
机标关键词：overviewmodelsbrainantshostdysfunctionsexperimentalfindings
论文发表日期：2024-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1908-1918 )
英文信息