Modulation of p75 neurotrophin receptor mitigates brain damage following ischemic stroke in mice
Golnoush Mirzahosseini1
Tauheed Ishrat2
1.Department of Anatomy and Neurobiology,College of Medicine,The University of Tennessee Health Science Center,Memphis,TN,USA;Pharmaceutical Sciences,College of Pharmacy,The University of Tennessee Health Science Center,Memphis,TN,USA2.Department of Anatomy and Neurobiology,College of Medicine,The University of Tennessee Health Science Center,Memphis,TN,USA;Pharmaceutical Sciences,College of Pharmacy,The University of Tennessee Health Science Center,Memphis,TN,USA;Neuroscience Institute,The University of Tennessee Health Science Center,Memphis,TN,USA
摘要：Stroke is a significant leading cause of death and disability in the United States(Tsao et al.,2022).Approximately 87％of strokes fall into the ischemic category,mainly caused by arterial blockage(Jayaraj et al.,2019).Although the only FDA-approved effective medication is tissue plasminogen activator(tPA),it should be administrated within 4.5 hours of ischemic stroke.Furthermore,tPA has been an integral part of managing acute ischemic stroke.However,it increases the development of intracerebral hemorrhage(Goncalves et al.,2022).Therefore,discovering a novel neuroprotective drug is a high clinical need.In recent years,there has been a significant increase in the utilization of thrombectomy procedures.
机标关键词：modulationreceptorstrokedamagebrainmicefollowingischemic
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2093-2094 )