Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity
Alessandro Cembran1
Pedro Fernandez-Funez2
1.Department of Chemistry and Biochemistry,University of Minnesota Duluth,Duluth,MN,USA2.Department of Biomedical Sciences,University of Minnesota Medical School,Duluth Campus,Duluth,MN,USA
摘要：The prion protein(PrP)is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of their unique familial,sporadic,and transmissible etiologies,all caused by a single agent:misfolded conformations of PrP.
机标关键词：dynamicsprionproteinconformationaldeterminantintrinsicmisfoldingneurotoxicity
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2095-2096 )