Pathogenic contribution of cholesteryl ester accumulation in the brain to neurodegenerative disorders
Michiko Shirane
Department of Molecular Biology,Graduate School of Pharmaceutical Sciences,Nagoya City University,Nagoya,Japan
摘要：Cholesteryl esters(CEs)have been increasingly implicated in neurodegenerative disorders such as Alzheimer's disease(AD).Alois Alzheimer noted three prominent neuropathologic features in his original analysis of the AD brain:senile plaques,neurofibrillary tangles,and lipid granule accumulation.Senile plaques,which are aggregates of amyloid-beta(Ap),and neurofibrillary tangles,which are aggregates of phosphorylated tau,have been regarded as more consistent characteristics of the AD brain compared with lipid granule accumulation and thus have been studied more intensively(Foley,2010).
机标关键词：neurodbrainaccumulationcholesterylcontributiondegenerativedisorderspathogenic
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2099-2100 )