Probing the endoplasmic reticulum-mitochondria interaction in Alzheimer's disease:searching far and wide
Giulia Dematteis
Laura Tapella
Dmitry Lim
Department of Pharmaceutical Sciences,Università del Piemonte Orientale"Amedeo Avogadro",Novara,Italy
摘要：Alzheimer's disease(AD)is the most frequent form of dementia in elderly people and is an incurable disease with an exponentially growing number of cases.Extracellular deposition of amyloid-β(Aβ)plaques and intraneuronal formation of neurofibrillary tangles represent neuropathological hallmarks of AD.A high failure rate of clinical trials,testing drugs aimed at either removal of Aβ or normalization of neuronal functions,suggests that the amyloid cascade hypothesis is not able to explain the complexity of AD pathogenesis,and the role of non-neuronal cells of the central nervous system,such as astroglial cells,should be considered.
机标关键词：alzheimerinteractiondiseaseendoplasmicmitochondriaprobingreticulumsearching
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2103-2104 )