Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases
Lei Cao1
Bin Ji2
Ruiqing Ni3
1.Changes Technology Corporation Ltd.,Shanghai,China;Fudan University,Shanghai,China2.School of Pharmacy,Fudan University,Shanghai,China3.Institute for Biomedical Engineering,University of Zurich & ETH Zurich Institute for Regenerative Medicine,University of Zurich,Zurich,Switzerland
摘要：Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseases is the aberrant cerebral accumulation of pathological protein aggregates,affecting selectively vulnerable circuits in a disease-specific pattern.Earlier studies have established a relationship between abnormal aggregation and neuronal dysfunction or loss,suggesting multifactorial pathogenesis mechanisms in these neurodegenerative disorders.
机标关键词：imagingneurodmodelsadvancesanimaldegenerativediseasesnon-invasive
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2115-2116 )