Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury
Nikita Ollen-Bittle1
Austyn D.Roseborough1
Wenxuan Wang1
Jeng-liang D.Wu2
Shawn N.Whitehead3
1.Department of Anatomy and Cell Biology,Western University,London,ON,Canada;Schulich School of Medicine and Dentistry,Western University,London,ON,Canada2.Department of Anatomy and Cell Biology,Western University,London,ON,Canada3.Department of Anatomy and Cell Biology,Western University,London,ON,Canada;Schulich School of Medicine and Dentistry,Western University,London,ON,Canada;Deparment of Clinical Neurological Sciences,Western University,London,ON,Canada
摘要：Traumatic brain injury is followed by a cascade of dynamic and complex events occurring at the cellular level.These events include:diffuse axonal injury,neuronal cell death,blood-brain barrier break down,glial activation and neuroinflammation,edema,ischemia,vascular injury,energy failure,and peripheral immune cell infiltration.The timing of these events post injury has been linked to injury severity and functional outcome.Extracellular vesicles are membrane bound secretory vesicles that contain markers and cargo pertaining to their cell of origin and can cross the blood-brain barrier.These qualities make extracellular vesicles intriguing candidates for a liquid biopsy into the pathophysiologic changes occurring at the cellular level post traumatic brain injury.Herein,we review the most commonly reported cargo changes in extracellular vesicles from clinical traumatic brain injury samples.We then use knowledge from animal and in vitro models to help infer what these changes may indicate regrading cellular responses post traumatic brain injury.Future research should prioritize labeling extracellular vesicles with markers for distinct cell types across a range of timepoints post traumatic brain injury.
机标关键词：vesiclebraincargoconnectingextracellularinjurymechanismstraumatic
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2119-2131 )
英文信息