Oligodendrocytes in central nervous system diseases:the effect of cytokine regulation
Chengfu Zhang1
Mengsheng Qiu2
Hui Fu3
1.Center for Cognition and Brain Disorders,The Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang Province,China;Department of Psychiatry,National Clinical Research Center for Mental Disorders,and National Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan Province,China2.institute of Life Sciences,Key Laboratory of Organ Development and Regeneration of Zhejiang Province,College of Life and Environment Sciences,Hangzhou Normal University,Hangzhou,Zhejiang Province,China3.Key Laboratory of Aging and Cancer Biology of Zhejiang Province,School of Basic Medical Sciences,Hangzhou Normal University,Hangzhou,Zhejiang Province,China
摘要：Cytokines including tumor necrosis factor,interleukins,interferons,and chemokines are abundantly produced in various diseases.As pleiotropic factors,cytokines are involved in nearly every aspect of cellular functions such as migration,survival,proliferation,and differentiation.Oligodendrocytes are the myelin-forming cells in the central nervous system and play critical roles in the conduction of action potentials,supply of metabolic components for axons,and other functions.Emerging evidence suggests that both oligodendrocytes and oligodendrocyte precursor cells are vulnerable to cytokines released under pathological conditions.This review mainly summarizes the effects of cytokines on oligodendrocyte lineage cells in central nervous system diseases.A comprehensive understanding of the effects of cytokines on oligodendrocyte lineage cells contributes to our understanding of central nervous system diseases and offers insights into treatment strategies.
机标关键词：centralsystemcytokinediseaseseffectnervousoligodendrocyteregulation
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 2132-2143 )
英文信息