Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression
Ying Ma1
Yue Qiao2
Xiang Gao3
1.Spinal Cord and Brain Injury Research Group,Stark Neuroscience Research Institute,Indianapolis,IN,USA;Department of Neurological Surgery,Indiana University School of Medicine,Indianapolis,IN,USA;Department of Neurology,Shengjing Hospital of China Medical University,Shenyang,Liaoning Province,China2.Department of Neurology,Shengjing Hospital of China Medical University,Shenyang,Liaoning Province,China3.Spinal Cord and Brain Injury Research Group,Stark Neuroscience Research Institute,Indianapolis,IN,USA;Department of Neurological Surgery,Indiana University School of Medicine,Indianapolis,IN,USA
摘要：It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms,such as paralysis,neuropathic pain,bladder/bowel dysfunction,and loss of sexual function,there are a variety of secondary complications,including memory loss,cognitive decline,depression,and Alzheimer's disease.The large-scale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients.Yet,few basic studies have been conducted to address the potential molecular mechanisms.One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity,social isolation,chronic pain,and elevated neuroinflammation after spinal cord injury.However,there is no clear consensus yet.In this review,we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury.Then,we will discuss possible mechanisms underlie this important spinal cord injury consequence.Finally,we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.
机标关键词：depressioncordrolehippocampalinducedinjuryneurogenesispost-trauma
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2144-2156 )
英文信息