Biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration
Shihong Zhu1
Xiaoyin Liu2
Xiyue Lu3
Qiang Liao4
Huiyang Luo5
Yuan Tian1
Xu Cheng3
Yaxin Jiang6
Guangdi Liu7
Jing Chen1
1.Department of Neurosurgery,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China2.Department of Neurosurgery,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China;National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu,Sichuan Province,China3.Department of Anesthesiology,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China4.Department of Pharmacy,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China5.Department of Neurosurgery,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China;Department of Anesthesiology,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China6.Out-patient Department,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China7.Department of Respiratory and Critical Care Medicine,West China Hospital,West China Medical School,Sichuan University,Chengdu,Sichuan Province,China
摘要：Traumatic brain injury is a serious medical condition that can be attributed to falls,motor vehicle accidents,sports injuries and acts of violence,causing a series of neural injuries and neuropsychiatric symptoms.However,limited accessibility to the injury sites,complicated histological and anatomical structure,intricate cellular and extracellular milieu,lack of regenerative capacity in the native cells,vast variety of damage routes,and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury.Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration.By combining biomaterials,stem cells,and growth factors,these approaches have provided a platform for developing effective treatments for neural injuries,which can offer the potential to restore neural function,improve patient outcomes,and reduce the need for drugs and invasive surgical procedures.Biomaterials have shown advantages in promoting neural development,inhibiting glial scar formation,and providing a suitable biomimetic neural microenvironment,which makes their application promising in the field of neural regeneration.For instance,bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu.Furthermore,stem cells-derived exosomes combine the advantages of stem cells,avoid the risk of immune rejection,cooperate with biomaterials to enhance their biological functions,and exert stable functions,thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function.Unfortunately,biomaterials have shown positive effects in the laboratory,but when similar materials are used in clinical studies of human central nervous system regeneration,their efficacy is unsatisfactory.Here,we review the characteristics and properties of various bioactive materials,followed by the introduction of applications based on biochemistry and cell molecules,and discuss the emerging role of biomaterials in promoting neural regeneration.Further,we summarize the adaptive biomaterials infused with exosomes produced from stem cells and stem cells themselves for the treatment of traumatic brain injury.Finally,we present the main limitations of biomaterials for the treatment of traumatic brain injury and offer insights into their future potential.
机标关键词：regenerationengineeringtissuebrainnovelbiomaterialsinjuryneural
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 2157-2174 )
英文信息