Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease
Dan Li1
Jinning Jia1
Haibo Zeng2
Xiaoyan Zhong1
Hui Chen3
Chenju Yi4
1.Department of Pathology,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi Province,China2.Department of Pathology,Huichang County People's Hospital,Ganzhou,Jiangxi Province,China3.School of Life Sciences,Faculty of Science,University of Technology Sydney,Ultimo,NSW,Australia4.Research Center,The Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen,Guangdong Province,China;Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research,Shenzhen,Guangdong Province,China;Guangdong Provincial Key Laboratory of Brain Function and Disease,Guangzhou,Guangdong Province,China
摘要：Alzheimer's disease(AD)is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions.While a definitive cure and optimal medication to impede disease progression are currently unavailable,a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition.Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD.Therefore,exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD.Herein,we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD,with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods,as well as the potential mechanisms underlying these positive effects.Specifically,we explain how exercise may improve the brain microenvironment and neuronal plasticity.In conclusion,exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction.Therefore,it can potentially become both a physical activity and a tailored intervention.This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease,especially in low-and middle-income countries.
机标关键词：rehabilitationalzheimerwithdiseaseefficacyexercisemanagingpatients
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 2175-2188 )
英文信息