Metabolic reprogramming of the inflammatory response in the nervous system:the crossover between inflammation and metabolism
Jesus Amo-Aparicio1
Charles A.Dinarello1
Ruben Lopez-Vales2
1.Department of Medicine,University of Colorado,Aurora,CO,USA2.institute of Neurosciences,and Department Cell Biology,Physiology and Immunology,Universitat Autònoma de Barcelona,Bellaterra,Spain;Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED),Instituto de Salud Carlos Ⅲ,Spain
摘要：Metabolism is a fundamental process by which biochemicals are broken down to produce energy(catabolism)or used to build macromolecules(anabolism).Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses.This was first identified in cancer cells as the Warburg effect,but it is also present in immunocompetent cells.Studies have revealed a bidirectional influence of cellular metabolism and immune cell function,highlighting the significance of metabolic reprogramming in immune cell activation and effector functions.Metabolic processes such as glycolysis,oxidative phosphorylation,and fatty acid oxidation have been shown to undergo dynamic changes during immune cell response,facilitating the energetic and biosynthetic demands.This review aims to provide a better understanding of the metabolic reprogramming that occurs in different immune cells upon activation,with a special focus on central nervous system disorders.Understanding the metabolic changes of the immune response not only provides insights into the fundamental mechanisms that regulate immune cell function but also opens new approaches for therapeutic strategies aimed at manipulating the immune system.
机标关键词：metabolicbetweensystemcrossoverinflammationinflammatorymetabolismnervous
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2189-2201 )
英文信息