A sphingolipid message promotes neuronal health across generations
Wenyue Wang
Roger Pocock
Development and Stem Cells Program,Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology,Monash University,Melbourne,VIC,Australia
摘要：Maternal nutrition can affect brain function of offspring in later life(Fitzgerald et al.,2020).Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease(Boots et al.,2023).Transmission of environmental information from mother to offspring depends on maternal nutrient provisioning.In the nematode Caenorhabditis elegans,maternal yolk,which is synthesized in the intestine and transferred to nourish oocytes and early embryos,can provide extranuclear inheritance factors to mediate phenotypic plasticity across generations.However,the molecular mechanisms of regulating such intergenerational effects remain largely unknown.
机标关键词：acrossgenerationshealthmessageneuronalpromotessphingolipid
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2325-2326 )