Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis
Valerie M.K.Verge
Nataliya Tokarska
Justin M.Naniong
Department of Anatomy,Physiology and Pharmacology,University of Saskatchewan,Saskatoon,SK,Canada;Cameco MS Neuroscience Research Center,University of Saskatchewan,Saskatoon,SK,Canada
摘要：Multiple sclerosis(MS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to disability.Inducing efficient and effective repair programs following demyelination is a major goal and challenge in MS.Conventional MS therapies focus largely on modulating the immune aspects of the disease contributing to lesions.While this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few MS patients experience,especially in the progressive phase of the disease.
机标关键词：strategyhypoxiarobustacuteinducingintermittentmultiplepotential
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2339-2340 )