Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control
Samuel K.H.Sy1
Ho Ko2
1.Division of Neurology,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China;Li Ka Shing Institute of Health Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China;Department of Electrical and Electronic Engineering,Faculty of Engineering,The University of Hong Kong,Pok Fu Lam,Hong Kong Island,Hong Kong Special Administrative Region,China;Advanced Biomedical Instrumentation Center,Hong Kong Science Park,Pak Shek Kok,New Territories,Hong Kong Special Administrative Region,China2.Division of Neurology,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China;Li Ka Shing Institute of Health Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China;Margaret K.L.Cheung Research Center for Management of Parkinsonism,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China;Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China;Gerald Choa Neuroscience Institute,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China
摘要：Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in animals.Nevertheless,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal subject.Moreover,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain imaging.Additionally,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much needed.This is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.
机标关键词：processingchemicalsthroughcontrolsmallanimalsfish-on-chipsfluidic
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 2351-2353 )