Unveiling DNA methylation in Alzheimer's disease:a review of array-based human brain studies
Victoria Cunha Alves1
Eva Carro2
Joana Figueiro-Silva3
1.Neurodegenerative Diseases Group,Hospital Universitario 12 de Octubre Research Institute(imas12),Madrid,Spain;Network Center for Biomedical Research,Neurodegenerative Diseases(CIBERNED),Madrid,Spain;Program in Neuroscience,Autonoma de Madrid University,Madrid,Spain;Neurotraumatology and Subarachnoid Hemorrhage Group,Hospital Universitario 12 de Octubre Research Institute(imas12),Madrid,Spain2.Network Center for Biomedical Research,Neurodegenerative Diseases(CIBERNED),Madrid,Spain;Neurobiology of Alzheimer's Disease Unit,Functional Unit for Research Into Chronic Diseases,Instituto de Salud Carlos Ⅲ,Madrid,Spain3.Institute of Medical Genetics,University of Zurich,Zurich,Switzerland;Department of Molecular Life Science,University of Zurich,Zurich,Switzerland
摘要：The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA methylation.This review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer's disease neuropathology.The examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer's disease progression.The entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the hippocampus.Notably,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal cortex.Further,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory processes.The complex role of BIN1 in late-onset Alzheimer's disease is underscored by its association with altered methylation patterns.Despite the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer's disease pathology.Future research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer's disease progression.
机标关键词：alzheimerreviewstudieshumanbrainarray-baseddiseasemethylation
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 2365-2376 )
英文信息