Human brain organoid:trends,evolution,and remaining challenges
Minghui Li1
Yuhan Yuan2
Zongkun Hou3
Shilei Hao2
Liang Jin2
Bochu Wang2
1.Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing,China;Southwest Hospital/Southwest Eye Hospital,Third Military Medical University(Army Medical University),Chongqing,China2.Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing,China3.School of Biology and Engineering/School of Basic Medical Sciences,Guizhou Medical University,Guiyang,Guizhou Province,China
摘要：Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases.Although various studies and reviews have described developments and advancements in brain organoids,few studies have comprehensively summarized and analyzed the global trends in this area of neuroscience.To identify and further facilitate the development of cerebral organoids,we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 years.First,annual publications,countries/regions,organizations,journals,authors,co-citations,and keywords relating to brain organoids were identified.The hotspots in this field were also systematically identified.Subsequently,current applications for brain organoids in neuroscience,including human neural development,neural disorders,infectious diseases,regenerative medicine,drug discovery,and toxicity assessment studies,are comprehensively discussed.Towards that end,several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.
机标关键词：evolutionhumanbrainchallengesorganoidremainingtrends
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2387-2399 )
英文信息