NLRP3/1-mediated pyroptosis:beneficial clues for the development of novel therapies for Alzheimer's disease
Bo Hu1
Jiaping Zhang2
Jie Huang2
Bairu Luo3
Xiansi Zeng2
Jinjing Jia2
1.Department of Pathology and Municipal Key-Innovative Discipline of Molecular Diagnostics,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing University,Jiaxing,Zhejiang Province,China2.Research Center of Neuroscience,Jiaxing University Medical College,Jiaxing,Zhejiang Province,China3.Department of Clinical Pathology,Jiaxing University Master Degree Cultivation Base,Zhejiang Chinese Medical University,Jiaxing,Zhejiang Province,China
摘要：The inflammasome is a multiprotein complex involved in innate immunity that mediates the inflammatory response leading to pyroptosis,which is a lytic,inflammatory form of cell death.There is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3(NLRP3)inflammasome-mediated microglial pyroptosis and NLRP1 inflammasome-mediated neuronal pyroptosis in the brain are closely associated with the pathogenesis of Alzheimer's disease.In this review,we summarize the possible pathogenic mechanisms of Alzheimer's disease,focusing on neuroinflammation.We also describe the structures of NLRP3 and NLRP1 and the role their activation plays in Alzheimer's disease.Finally,we examine the neuroprotective activity of small-molecule inhibitors,endogenous inhibitor proteins,microRNAs,and natural bioactive molecules that target NLRP3 and NLRP1,based on the rationale that inhibiting NLRP3 and NLRP1 inflammasome-mediated pyroptosis can be an effective therapeutic strategy for Alzheimer's disease.
机标关键词：pyroptosisdevelopmentalzheimernlrp3novel1-mediatedbeneficialclues
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 2400-2410 )
英文信息