Inhibition of tubulin detyrosination:a novel strategy to promote central nervous system regeneration
Charlotte Zeitler
Marco Leibinger
Dietmar Fischer
Center of Pharmacology,Institute for Pharmacology,Medical Faculty and University of Cologne,Cologne,Germany
摘要：The adult mammalian central nervous system(CNS)coordinates essential functions such as sensation,movement,autonomic control,thought processes,and communication.Consequently,injuries or diseases of the CNS are often associated with devastating and permanent functional impairments because damaged axons normally fail to regenerate.An insufficient neuron-intrinsic growth capacity and an inhibitory environment at the injury site are the leading causes of this regenerative failure.Although numerous strategies addressing these issues have enabled considerable axon regeneration in various experimental injury models,clinically applicable treatment options or drugs promoting functional recovery are not yet available.
机标关键词：regenerationinhibitiontubulinstrategycentralsystemnoveldetyrosination
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2557-2558 )