Apoer2/Lrp8:the undercover cop of synaptic homeostasis
Gordon C.Werthmann1
Joachim Herz2
1.Department of Molecular Genetics and Center for Translational Neurodegeneration Research,University of Texas Southwestern Medical Center at Dallas,Dallas,TX,USA2.Department of Molecular Genetics and Center for Translational Neurodegeneration Research,University of Texas Southwestern Medical Center at Dallas,Dallas,TX,USA;Department of Neuroscience;Department of Neurology;University of Texas Southwestern Medical Center at Dallas,Dallas,TX,USA
摘要：Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of synaptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric disorders.In this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.
机标关键词：apoer2homeostasissynapticundercover
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2563-2564 )