Strain-dependent alpha-synuclein spreading in Parkinson's disease and multiple system atrophy
Shuyu Zhang1
Paul Lingor2
1.Department of Neurology,School of Medicine,University Hospital rechts der Isar,Technical University of Munich,Munich,Germany2.Department of Neurology,School of Medicine,University Hospital rechts der Isar,Technical University of Munich,Munich,Germany;Department of Neurology,University Medical Center Göttingen,Göttingen,Germany;Center for Biostructural Imaging of Neurodegeneration,University Medical Center Göttingen,Göttingen,Germany
摘要：Parkinson's disease(PD)and atypical Parkinsonian syndromes,such as multiple system atrophy(MSA)and Dementia with Lewy bodies,are neurodegenerative movement disorders characterized by the accumulation of alpha-synuclein(α-syn)aggregates.These α-syn aggregates propagate throughout the brain in a prion-like manner,where pathological α-syn recruits endogenous α-syn to form insoluble aggregates.Oligomeric forms representing intermediates on the way to insoluble aggregates result in the most pronounced neurotoxic effects.
机标关键词：parkinsonstrainsystemalpha-synucleinatrophydependentdiseasemultiple
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2581-2582 )