Bone marrow-derived microglia confer neuroprotection to a mouse model of amyotrophic lateral sclerosis
Beka Solomon
Department of Molecular Microbiology and Biotechnology,The Shmunis School of Biomedicine and Cancer Research,the George S.Wise Faculty of Life Sciences Tel-Aviv University,Ramat Aviv,Israel
摘要：Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease that causes the progressive loss of both upper and lower motor neurons in the brain,brainstem,and spinal cord.The exact mechanisms of ALS are still unclear,but genetic and molecular studies have revealed some key factors that may contribute to motor neuron death.Besides motor neurons,other cell types in the nervous system,such as reactive astrocytes and activated microglia,also show pathological changes and secrete harmful substances and inflammatory cytokines(Appel et al.,2011).
机标关键词：mousemodelamyotrophicboneconferlateralmarrow-derivedmicroglia
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2586-2587 )